Dr. Jonathan Gubbay

Areas of Expertise

• respiratory viruses
• gastrointestinal viruses
• arboviruses
• viral molecular epidemiology

Appointments

Associate Professor, Laboratory Medicine and Pathobiology, University of Toronto

Associate Professor, Paediatrics, University of Toronto

Staff physician (part-time), Division of Infectious Diseases, Paediatrics, The Hospital for Sick Children, Toronto

Academic Degrees and Accreditations

• Bachelor of Medicine and Bachelor of Surgery (Medicine), Faculty of Medicine, University of New South Wales
• Master of Medical Science (Clinical Epidemiology), University of Newcastle

PHO Research Interests

• molecular investigation of respiratory viral pathogens
• antiviral resistance in influenza
• applying molecular methods to understanding the molecular epidemiology and genetic heterogeneity of respiratory viruses

PHO Research Activities

• Exploring the clinical utility of viral load measurements of respiratory viruses to better understand: (1) the interplay of viral genetics with clinical presentation and severity of respiratory viral infections (2) whether such quantitation of respiratory viruses can be used to predict infectivity and guide infection control approaches, in particular periods of isolation.
• Evaluating the correlation between viral load and clinical severity/prognosis.
• Surveillance on neuraminidase inhibitor resistance in influenza viruses and evaluating novel drugs for antiviral effects on influenza and other respiratory viruses.
• Developing multiplex assays to be used in certain clinical settings such as fever, rash and sepsis, when a multitude of viruses and bacteria could give an identical clinical presentation.

Selected Publications

1. Isabel S, Higgins RR, Peci A, Isabel MR, Deeks SL, Gubbay JB. Rotavirus genotypes circulating in Ontario, Canada, before and after implementation of the rotavirus immunization program. Vaccine. 2018;36(15):2033-40.
2. Eshaghi A, Duvvuri VR, Isabel S, Banh P, Li A, Peci A, Patel SN, Gubbay JB. Global distribution and evolutionary history of Enterovirus D68, with emphasis on the 2014 outbreak in Ontario, Canada. Front Microbiol. 2017;8:257.
3. Granados A, Peci A, McGeer A, Gubbay JB. Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections. J Clin Virol. 2017;86:14-9.
4. Duvvuri VR, Granados A, Rosenfeld P, Bahl J, Eshaghi A, Gubbay JB. Genetic diversity and evolutionary insights of respiratory syncytial virus A ON1 genotype: global and local transmission dynamics. Sci Rep. 2015;5:14268.
5. Eshaghi A, Duvvuri VR, Lai R, Nadarajah JT, Li A, Patel SN, Low DE, Gubbay JB. Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication. PLoS One. 2012;7(3):e32807.

View more publications by Dr. Jonathan Gubbay on PubMed.gov